414 papers
Cell biology is the study of life at its most fundamental unit: the cell. This field explores how these microscopic building blocks function, communicate, and replicate to sustain living organisms, from the simplest bacteria to complex human tissues. By understanding the machinery inside a cell, scientists unlock secrets about growth, disease, and the very nature of existence itself.
At Gist.Science, we track every new preprint uploaded to bioRxiv within this dynamic category. Our team processes each submission to provide both accessible plain-language explanations and detailed technical summaries, ensuring you can grasp complex discoveries without getting lost in dense jargon. Below are the latest papers in cell biology, offering a fresh look at the inner workings of life as they are shared with the world.
This study establishes a practical framework for cell culture research by validating a low-temperature paraformaldehyde vapor sterilization method for 3D-printed FFF components and identifying compatible materials, including necessary post-treatments to ensure biocompatibility.
This study demonstrates that in *C. elegans*, the conserved cofactor DSB-1 (Rec114) has evolutionarily replaced TOPOVIBL to stabilize SPO-11 complex formation and promote its dimerization, thereby ensuring the regulated generation of meiotic DNA double-strand breaks necessary for genomic stability.
This study reveals that the non-pathogenic model *Naegleria gruberi* exhibits confinement-seeking behavior and persistent, rapid, bleb-based motility within narrow channels and 3D matrices, suggesting these traits are evolutionary adaptations that prime the pathogenic *Naegleria fowleri* for its deadly migration into the human brain.
This study reveals that the Anaphase Promoting Complex (APC) targets the toxic protein progerin for degradation via an autophagy-dependent, proteasome-independent pathway, offering a novel mechanism for reversing Hutchinson-Gilford Progeria Syndrome phenotypes and linking APC function to aging.
This study introduces a DNA barcoding-based paired daughter cell assay to demonstrate that hematopoietic stem cell divisions are biased toward symmetric outcomes (stem-stem or progenitor-progenitor) and reveals a continuum of HSC states linking these division patterns to specific molecular signatures.
This study identifies Peroxiredoxin 6 (PRDX6) as a conserved regulator that limits mitochondrial lipid peroxidation under mild oxidative stress to prevent excessive mitochondrial-ER contact site assembly, calcium dysregulation, and subsequent inflammatory signaling.
This study introduces a quantitative single-molecule mapping toolkit to reveal that right ventricular failure drives spatially heterogeneous remodeling of RyR2-JPH2 nanodomains, which alters local stoichiometry and cell-wide organization to dysregulate calcium signaling and promote spontaneous calcium waves.
This study identifies a conserved mechanism in *Schizosaccharomyces pombe* where domain-specific receptors, such as the nucleolar protein Dnt1, interact with a specific surface on the cohesin loader Scc4/Ssl3 to direct targeted cohesin loading, thereby organizing specialized chromosomal domains like centromeres and rDNA through loop extrusion without disrupting global chromosome architecture.
This study demonstrates that heparan sulfate chains orchestrate the nanoscale organization and dynamics of Glypican-3 on hepatoma cells, facilitating the assembly of GPC3-Wnt receptor complexes to drive efficient Wnt/-catenin signaling.
This study reveals that the Dip2-Pkc1 signaling axis maintains mitochondrial integrity in eukaryotes by utilizing a specific lipid acyl code of diacylglycerols to recruit Pkc1 to mitochondria, thereby regulating organelle morphology and function during respiratory growth.